Chromosomal passengers

Not to be confused with... CENP-E, chromokinesin, Polo kinase... A number of proteins are localised a bit like chromosomal passengers. However these proteins occupy slightly different locations on the chromosomes: the kinetochore for CENP-E and Polo; all along the chromosome arms for chromokinesin. Some of these proteins may interact functionally or physically with the passenger proteins. Strangest behaviour... Canonical passenger proteins accumulate in the inner centromeres during metaphase prior to transferring to the spindle midzone at anaphase. If chromosomal passengers do not first concentrate at centromeres, it seems they are not able to move on to the central spindle and midbody later in mitosis. No one knows what is so special about the inner centromere.